SN Iyer (Lions (-3.5, 50.5 o/u) at Panthers - Sunday 8:20 p.m. ET, NBC and Peacock. The Lions will use plenty of Jahmyr Gibbs to set the tone running on the Panthers' weakn run defense. They also will try to stretch the field better in the passing game with Amon-Ra St. Brown and Jameson Williams. Bryce Young will be game to make it close late with Tetairoa McMillan and a variety of weapons. Detroit will just need to get used to trying to win shootouts every week. Pick: Lions win 27-24 but fail to cover the spread.): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-against-spread-week-4/644a1b752369664e0ee8c218
SN Bender (Detroit Lions (-3) at Carolina Panthers - Sunday, 8:20 p.m., NBC. Bryce Young leads the NFL with 313 passing yards per game, but the lack of run support showed against Cleveland in Week 3. Carolina will have more success against a struggling Detroit defense, but how will they slow down Jahmyr Gibbs, who ranks second in the NFL with 11 carries of 10 yards or more, according to PFF.com. This feels like another Sunday Night Football scoring fest. Pick: Lions 34, Panthers 28): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-4/d770d8401c10e9e74b6e687b
CBS Prisco (Detroit Lions (-3.5) at Carolina Panthers - Sunday, 8:20 p.m. on NBC (Stream: Fubo -- try for free). The Panthers are really banged up and Bryce Young is hurting to go with a bunch of other injuries. They played short-handed in the loss to the Browns last week. The Lions won a high-scoring game with the Jets Sunday and this one will be just like it. Look for Jared Goff to play well here as the Lions win a road game. Pick: Lions 31, Panthers 26): https://www.cbssports.com/nfl/news/pete-priscos-week-4-nfl-picks/
CBS Sullivan (Lions at Panthers - Projected score: Lions 30, Panthers 27): https://www.cbssports.com/nfl/news/nfl-week-4-picks-odds-packers-road-teams/
NFL.com (All 10 pick the Lions to win by scores of 30-21, 26-23, 31-24, 38-28, 31-28, 31-27, 37-28, 33-31, 28-25, 29-22): https://www.nfl.com/videos/lions-vs-panthers-preview-week-4
Pro Picks: Patrick Mahomes and the Chiefs will hand the Raiders their first loss (DETROIT (2-1) at CAROLINA (1-2) - Line: Lions minus 3. Detroit’s prolific offense is averaging 31 points per game, but the defense is giving up a league-worst 31.7. Jared Goff will face a depleted defense that likely won’t have its starting cornerbacks. That’s bad news for Carolina. Bryce Young and the Panthers have to win a shootout. LIONS: 31-26): https://apnews.com/article/pro-picks-2026-week-4-277f0655698feb249482a57cec4ea62a
Football Meteorology For NFL Week 4 (Detroit Lions at Carolina Panthers (+3.5): Carolina enters this game without both its starting CBs, who went on I.R. this week. They’re also going to be without top offensive lineman Damien Lewis, which is really bad news against a Lions defensive front that is playing better than Detroit’s overall defensive statistics would have you believe. The Lions have scored exactly 31 points in all three games thus far. It would be a moral victory for the Panthers to hold Jared Goff, Jahmyr Gibbs, Amon-Ra St. Brown and friends to just 31 in this one. Lions 37, Panthers 24): https://football.realgm.com/analysis/3718/Football-Meteorology-For-NFL-Week-4
NFL Week 4 picks: Upset and score predictions, matchup breakdowns for every game (All 5 pick the Lions to win by scores of 41-35, 26-23, 30-23, 34-31, 37-28): https://www.nfl.com/news/nfl-picks-week-4-2026-nfl-season
CBS Dajani, Dubin (Detroit Lions (-3.5) at Carolina Panthers (SNF) - Dajani (Lions -3.5): I'm a bit partial to the Lions despite their horrific defense. We got the cover last week vs. the New York Jets, but it was quite a sweat. I'm taking the Lions this week because of the Panthers' injury situation. They will not have their two starting cornerbacks on the field in Jaycee Horn or Mike Jackson. Keep in mind this Panthers defense is already statistically one of the worst in the NFL and had 552 total yards and 59 points dropped on them in their last home game. The Lions are simply going to outscore the Panthers in primetime, and I think we could be looking at a blowout. The Lions are 11-0 SU and 9-1-1 ATS in primetime games as favorites under Dan Campbell. Get ready for some points. … Prediction: Lions 35, Panthers 21. Dubin (Lions -3.5): Lions games have turned into track meets so far this season, with Detroit scoring at least 30 points in every game. With the Panthers likely down their top two cornerbacks, this week is set up for them to go off yet again. We might even see Jameson Williams really pop off for the first time this year. And we know both Jahmyr Gibbs and Amon-Ra St. Brown will be productive. Bryce Young is leading the NFL in passing yards, but he might not have Jalen Coker here, so the Panthers might not have quite enough to compete here, even given how bad the Lions' defense is. … Prediction: Lions 34, Panthers 24): https://www.cbssports.com/nfl/news/nfl-week-4-picks-our-experts-predictions/
PFT’s Week 4 2026 NFL picks (Lions at Panthers - The Panthers have carried over less of the “division champs” vibe and more of the “8-9-for-a-reason” vibe. And the Lions definitely can’t afford to lose games they should win. Lions 31, Panthers 21.): https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-4-2026-nfl-picks
TheBigLead (Detroit Lions vs. Carolina Panthers (8:20 p.m. ET, NBC/Peacock) - Jared Goff and the Lions have an elite offense, and that will keep them in many games this season. Detroit just needs to expect more from their defense in order to put the Lions in the Super Bowl conversation. Pick: Lions 31, Panthers 20): https://www.thebiglead.com/nfl-week-4-picks-predictions-patriots-lose-control-afc-east/
Our guide to every NFL Week 4 game: Matchup previews, predictions, picks and nuggets (Maldonado's pick: Lions 31, Panthers 24. Moody's pick: Lions 31, Panthers 28. Walder's pick: Lions 34, Panthers 14): https://www.espn.com/nfl/story/_/id/50067784/week-4-picks-predictions-schedule-fantasy-odds-2026
Lions vs. Panthers Prediction Lab: Detroit has some major advantages, but one problem could keep Carolina in this game (Final prediction - I’ve got the Lions winning. There’s just too much going on in Carolina with injuries, and if any team knows how hard that is to overcome, it’s Detroit. I think the Lions offense succeeds against this defense, and this could be the get-right game the defense needs. Lions 31, Panthers 14. That’s right, 31 again. That would tie an NFL record for the same point total in four straight games. So I’m going with the Lions setting a record and winning in prime time. Then there’s one more game before the bye. We’ll see what happens.): https://atozsports.com/nfl/detroit-lions-news/lions-vs-panthers-prediction-lab-detroit-has-some-major-advantages-but-one-problem-could-keep-carolina-in-this-game/
Carolina Panthers OnSI (All 4 pick the Lions to win by scores of 28-26, 38-27, 38-31, 31-27): https://www.si.com/nfl/panthers/onsi/will-the-panthers-beat-the-lions-staff-predictions-snf
MLive.com Lions-Panthers Week 4 score predictions from MLive’s beat writers (All 3 pick the Lions to win by scores of 35-20, 35-17, 31-21): https://www.mlive.com/lions/2026/10/lions-panthers-week-4-score-predictions-from-mlives-beat-writers.html
Expert Predictions For Detroit Lions Matchup With Carolina Panthers (All 4 pick the Lions to win by scores of 30-20, 34-24, 27-23, 31-28) (10-3-26): https://www.si.com/nfl/lions/onsi/expert-predictions-for-detroit-lions-matchup-with-carolina-panthers
Detroit Lions at Carolina Panthers NFL Prediction, Picks & Odds for Week 4 SNF (Lions 28 – Panthers 24): https://athlonsports.com/nfl/detroit-lions-at-carolina-panthers-nfl-prediction-picks-odds-week4-2026
NFL Week 4 expert picks, score predictions: Lions at Panthers (All 13 pick the Lions to win by scores of 37-27, 42-20, 31-21, 37-31, 35-24, 34-13, 31-27, 38-21, 31-26, 27-20, 45-20, 38-24, 27-24): https://www.prideofdetroit.com/detroit-lions-analysis/175511/detroit-lions-carolina-panthers-nfl-week-4-expert-picks-score-predictions
USA Today (5 pick the Lions to win by scores of 34-30, 38-31, 30-27, 30-27, 34-20. 1 picks the Panthers to win 33-30): https://www.usatoday.com/story/sports/nfl-picks/2026/10/01/nfl-week-4-picks-spread-predictions-locks-chiefs-raiders-cowboys-texans/92026107007/
Detroit News (All 4 pick the Lions to win by scores of 38-28, 27-21, 38-28, 31-17): https://www.detroitnews.com/story/sports/nfl/lions/2026/10/03/predictions-lions-at-carolina-panthers/92016462007/
Panthers vs. Lions prediction: Explosive offenses poised for potential 'Sunday Night Football' shootout (Prediction - Carolina will have no answers for Amon-Ra St. Brown without its top two cornerbacks, and Jahmyr Gibbs has never seen a defense he cannot torch. And on the other side of the ball, the Lions own a beleaguered secondary of their own, and there is no reason to believe the league's worst pass defense will keep Bryce Young in check — especially if wide receiver Jalen Coker returns to the lineup. The Panthers posted 37 points in their Week 1 home shootout with the Chicago Bears and could outdo that number against an even leakier defense. In a game where one stop might be the difference, the home team holds the edge. Pick: Panthers 38, Lions 34): https://www.cbssports.com/nfl/news/panthers-vs-lions-where-to-watch-pick-odds-prediction/
Non-Score Predictions:
CBS (All 4 pick the Lions to win): https://www.cbssports.com/nfl/picks/experts/straight-up/4/
ESPN (10 pick the Lions to win. 1 picks the Panthers to win): https://www.espn.com/nfl/picks
FTW (7 pick the Lions to win. 1 Picks the Panthers): https://ftw.usatoday.com/story/sports/nfl/2026/10/01/nfl-straight-up-picks-week-4-steelers-browns-broncos-49ers/92020754007/
SI (6 pick the Lions to win. 2 pick the Panthers to win): https://www.si.com/nfl/week-4-picks-staff-expert-predictions
---------------
89 Pick the Lions to win. 6 Pick the Panthers to win. Average Predicted Score (2164-1627/66): Lions 33 Panthers 25