SN Iyer (Lions (-4.5, 53.5 o/u) at Cardinals - Sunday 4:25 p.m. ET, Fox. The Lions' defense gets Mike LaFleur's offense, which doesn't mind staying relentless with the pass from Jacoby Brissett with Trey McBride and Michael Wilson causing matchup problems. On the flip, Jared Goff gets comfortable on the road as Arizona can't slow down Jahmyr Gibbs, Amon-Ra St. Brown, Jameson Williams or Sam LaPorta. There will be some fireworks in the desert and the Lions will come ready to rule the Cards' roost. Pick: Lions win 31-27 but fail to cover the spread.): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-against-spread-week-5/eca9ea6e41412f089384daf3
SN Bender (Detroit Lions (-4.5) at Arizona Cardinals - Sunday, 4:25 p.m., Fox. The Lions' defense is struggling. Detroit is allowed a league-worst 304 passing yards per game, and a high-volume passer like Jacoby Brissett can have success against that coverage. The Cardinals, however, have given up 30 or more points in three of four games. Detroit can engage in a wild shootout – especially if Jared Goff, who averages 369 passing yards in two road starts, can stay in command. Pick: Lions 31, Cardinals 24): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-5/04787d3ef5247c02e1b96a88
Pro Picks: Rams will edge the Bills on Monday night in potential Super Bowl preview (DETROIT (2-2) at ARIZONA (1-3) - Line: Lions minus 5 ½. The Lions have a potent offense. Problem is the defense is terrible, allowing the most yards and points in the league. Jared Goff and Co. should put up points against Arizona. Jacoby Brissett shouldn’t have any trouble doing the same for the Cardinals. That’s why the over/under 54 ½. LIONS: 31-27): https://apnews.com/article/nfl-pro-picks-week-5-599dea3fdb254db7efde736644fd59f9
Video - Lions vs. Cardinals preview | Week 5 (All 10 pick the Lions to win by scores of 31-24, 30-27, 31-30, 34-31, 28-23, 31-25, 30-27, 31-27, 30-20, 27-19): https://www.nfl.com/videos/lions-vs-cardinals-preview-week-5
CBS Prisco (Detroit Lions (-4.5) at Arizona Cardinals - The Lions are playing on the road off a Sunday night loss. They can't stop anybody on defense. But the Cardinals have some defensive issues as well. Look for the Lions to outscore Arizona in a shootout as Jared Goff puts up big numbers. Pick: Lions 40, Cardinals 31): https://www.cbssports.com/nfl/news/pete-priscos-week-5-nfl-picks-odds/
CBS Sullivan (Lions at Cardinals - Projected score: Lions 33, Cardinals 30): https://www.cbssports.com/nfl/news/nfl-week-5-picks-predictions-bets-jaguars-eagles-2026/
USA Today (All 6 pick the Lions to win by scores of 31-27, 38-24, 38-31, 31-27, 31-24, 38-31): https://www.usatoday.com/story/sports/nfl-picks/2026/10/08/nfl-week-5-picks-spread-predictions-locks-rams-bills-49ers-seahawks/92134394007/
PFT’s Week 5 2026 NFL picks (Lions at Cardinals - Whether Dan Campbell likes it or not, the Lions are mediocre. Fortunately for Detroit, the Cardinals are less than mediocre. Lions 24, Cardinals 23.): https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-5-2026-nfl-picks
NFL Week 5 picks: Upset and score predictions, matchup breakdowns for every game (All 5 pick the Lions to win by scores of 35-27, 30-27, 42-24, 33-27, 32-26): https://www.nfl.com/news/nfl-picks-week-5-2026-nfl-season
Football Meteorology For NFL Week 5 (Detroit Lions at Arizona Cardinals (+6.5): This is the “something’s gotta give” bowl. No team generates fewer explosive plays on offense than the Cardinals, by far. No team allows big plays more than Detroit’s defense, by far. The resistible force meets the moveable object. Unfortunately for the Cardinals, their defense is just above Detroit’s in explosive plays allowed, and they have to try and stop Jared Goff, Amon-Ra St. Brown, Jahmyr Gibbs and a Lions offense that’s in the top six in both points and yards per game. Lions 38, Cardinals 31): https://football.realgm.com/analysis/3721/Football-Meteorology-For-NFL-Week-5
TheBigLead Reed (Detroit Lions at Arizona Cardinals (4:25 p.m., Fox) - Neither team plays a lot of defense, but that makes for some exciting offensive football. Jared Goff and Jahymr Gibbs expand on their hot starts to the year and get back in the win column. Pick: Lions 34, Cardinals 31): https://www.thebiglead.com/nfl-week-5-picks-predictions-49ers-dethrone-super-bowl-champs/
Our guide to every NFL Week 5 game: Matchup previews, predictions, picks and nuggets (Maldonado's pick: Lions 34, Cardinals 27. Moody's pick: Lions 33, Cardinals 23. Walder's pick: Lions 30, Cardinals 20): https://www.espn.com/nfl/story/_/id/50129471/week-5-picks-predictions-schedule-fantasy-odds-2026
Lions vs. Cardinals prediction: Where Detroit can win, what could get the Lions beat and our Week 5 pick (Final score prediction - Stop McBride, keep Goff clean, get the run game going, and stop Arizona’s run game. If those things happen, the Lions walk out with a win. I don’t think it’s a blowout, though. I have the Lions winning 31-28, with kicker Jake Bates hitting a game-winning field goal to end it. We’ll probably come away thinking that Detroit’s defense needs all the help it can get. Hopefully, the Lions go out and get it during the bye week. We’ll see how it plays out on Sunday.): https://atozsports.com/nfl/detroit-lions-news/lions-vs-cardinals-prediction-where-detroit-can-win-what-could-get-the-lions-beat-and-our-week-5-pick/
CBS Dajani (Lions 30-28 over Cardinals): https://www.cbssports.com/nfl/news/nfl-week-5-picks-odds-steelers-bounce-back-browns-upset-jets/
Cardinals OnSI (Our Own Prediction - This is shaping up to be a fun one at State Farm Stadium, as Week 5 could very well turn into a track meet. We like the Lions to win that race. DET 30, AZ 24.): https://www.si.com/nfl/cardinals/onsi/arizona-cardinals-detroit-lions-week-5-expert-picks-prediction-roundup
Lions vs. Cardinals Score Prediction for NFL Week 5 (Can Detroit Get First Road Win?) (Final Score Prediction: Detroit 38, Cardinals 24): https://www.si.com/betting/lions-vs-cardinals-score-prediction-for-nfl-week-5-can-detroit-get-first-road-win-01m4c551ha73
Dueling expert picks for Lions vs. Cardinals in Week 5 (Both pick the Lions to win by scores of 41-31, 34-27): https://cardswire.usatoday.com/story/sports/nfl/cardinals/2026/10/10/dueling-expert-picks-for-lions-vs-cardinals-in-week-5/92196954007/
Expert Predictions For Detroit Lions Matchup With Arizona Cardinals (All 4 pick the Lions to win by scores of 31-28, 27-23, 38-31, 37-24): https://www.si.com/nfl/lions/onsi/expert-predictions-for-detroit-lions-matchup-with-arizona-cardinals
Detroit Lions at Arizona Cardinals NFL Prediction, Picks & Odds for Week 5 (Lions 28 – Cardinals 24): https://athlonsports.com/nfl/detroit-lions-at-arizona-cardinals-nfl-prediction-picks-odds-week5-2026
NFL Week 5 expert picks, score predictions: Lions at Cardinals (All 13 pick the Lions to win by scores of 34-27, 38-24, 42-17, 38-37, 31-27, 33-20, 31-24, 38-17, 30-25, 33-30, 45-20, 34-31, 30-20): https://www.prideofdetroit.com/detroit-lions-analysis/176463/detroit-lions-arizona-cardinals-nfl-week-5-expert-picks-score-predictions
Detroit News (All 4 pick the Lions to win by scores of 31-28, 34-24, 31-28, 38-27): https://www.detroitnews.com/story/sports/nfl/lions/2026/10/10/predictions-lions-at-arizona-cardinals/92125993007/
Lions-Cardinals Week 5 score predictions from MLive’s beat writers (2 pick the Lions to win by scores of 31-23, 35-28. 1 picks the Cardinals to win 27-21): https://www.mlive.com/lions/2026/10/lions-cardinals-week-5-score-predictions-from-mlives-beat-writers.html
TheBigLead Mastro (Detroit Lions (2-2) @ Arizona Cardinals (1-3): We think this game will be a shootout as neither of these teams seem to care about playing defense nearly as much as they love scoring points. The Lions venture to the desert to the former home of their offensive coordinator, Drew Petzig. The public thinks that Detroit will have little trouble in taking care of business here, but we say “not so fast my friend”. Look for the Cardinals to pick up where the Carolina Panthers left off last week, and they will attack this Detroit defense through the air with both Tre McBride and Michael Wilson. Give us the Cardinals for the upset win in a high-scoring affair. Final Score: Cardinals 37 – Lions 35): https://www.thebiglead.com/predicting-upsets-week-5-2026-nfl-season/
Non-Score Predictions:
ESPN (11 pick the Lions to win): https://www.espn.com/nfl/picks
FTW (All 6 pick the Lions to win): https://ftw.usatoday.com/story/sports/nfl/2026/10/08/nfl-moneyline-straight-up-picks-week-5-patriots-raiders-browns-jets-bills-rams/92138126007/
CBS (All 5 pick the Lions to win): https://www.cbssports.com/nfl/picks/experts/straight-up/5/
SI (5 pick the Lions to win. 3 pick the Cardinals to win): https://www.si.com/nfl/week-5-picks-staff-expert-predictions
88 Pick the Lions to win. 5 Pick the Cardinals to win. Average Predicted Score (2103-1646/63): Lions 33 Cardinals 26
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