SN Iyer ( Upset of the Week: Lions (+5.5, 54 o/u) over Rams - The Lions are feeling confident in their offense again in this latest QB duel between former Ram Jared Goff and former Lion Matthew Stafford. The Rams can move the ball well on Detroit's defense, but Los Angeles also has plenty of holes to exploit on the back end. Between Amon-Ra St. Brown, Jameson Williams, Jahmyr Gibbs, Puka Nacua, Davante Adams and Kyren Williams, there's too much receiver and back talent not to expect a SoFi shootout. The Lions steal it late with a lot of Gibbs. Pick: Lions win 34-31.): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-against-spread-week-15-packers-edge-broncos-patriots-complete-sweep-bills/de25d3f5a74b05cc2acabe34
Pro Pick Rob Maadi (DETROIT (8-5) at LOS ANGELES RAMS (10-3) - Line: Rams minus 5 1/2. Jared Goff is 2-1 against Matthew Stafford, including a playoff win, since they were traded for each other. But the Rams got their Super Bowl victory with Stafford while the Lions are still trying to get to one. They’ve got a tough road to even get in the playoffs, starting this week. Goff and coach Dan Campbell are 23-12 ATS as underdogs. The Rams are 16-3 ATS in December since 2021. Something has to give. UPSET SPECIAL: LIONS: 27-26): https://apnews.com/article/nfl-line-picks-broncos-patriots-packers-bills-be40224250281d9b87312c0641601a90
Five things to watch as Lions look to improve playoff chances with win over the Rams (PREDICTION: Lions 28, Rams 27): https://lionslowdown.com/2025/12/13/five-things-to-watch-as-lions-look-to-improve-playoff-chances-with-win-over-the-rams/
Our guide to every Week 15 NFL game: Matchup previews, predictions and what's at stake (Maldonado's pick: Lions 45, Rams 42. Moody's pick: Lions 31, Rams 28. Walder's pick: Rams 30, Lions 24): https://www.espn.com/nfl/story/_/page/viewersguide47256881/nfl-week-15-picks-predictions-schedule-fantasy-football-odds-injuries-stats-2025
Freep (2 pick the Lions to win by scores of 36-31, 35-32. 4 pick the Rams to win by scores of 31-24, 34-24, 31-23, 34-30): https://www.freep.com/story/sports/nfl/lions/2025/12/14/rams-lions-game-picks-predictions/87731062007/
Lions OnSI (1 picks the Lions to win 38-35. 3 Pick the Rams to win by scores of 35-30, 37-30, 27-24): https://www.si.com/nfl/lions/onsi/news/expert-predictions-will-detroit-lions-defeat-los-angeles-rams
USA Today (1 picks the Lions to win 31-30. 5 pick the Rams to win by scores of 34-24, 34-31, 30-27, 27-24, 30-21): https://www.usatoday.com/story/sports/nfl-picks/2025/12/11/nfl-week-15-picks-spread-predictions-locks-chiefs-patriots-bills/87713059007/
NFL.com Video Lions vs. Rams preview | Week 15 (1 picks the Lions to win 24-21. 9 pick the Rams to win by scores of 27-26, 30-27, 31-27, 26-25, 27-25, 31-28, 28-27, 30-25, 30-27): https://www.nfl.com/videos/lions-vs-rams-preview-week-15
SN Bender (Detroit Lions at Los Angeles Rams (-5.5) - The key for both teams will be the running game. Jahmyr Gibbs (5.7 yards per carry) and Kyren Williams (4.9 yards per carry) can control a high-stakes game like this. Turnovers also will be huge. The Rams are 4-1 S/U at home this season, and three of those games have been one-score victories. Pick: Rams 28, Lions 24): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-15/4967edab19eedbb80cd144c0
Walter football (Week 15 NFL Pick: Rams 38, Lions 24): https://walterfootball.com/nflpicks2025_15late.php
CBS Prisco (Detroit Lions at Los Angeles Rams (-5.5): This is a big game in terms of playoff seeding. The Lions are 8-5 and can't afford another loss, while the Rams are pushing for a division title and the top seed. The Rams offense got back on track last week and the Lions have issues on defense. That's a bad combination. Look for Matthew Stafford to light things up against his former team, while Jared Goff can't keep up. Rams win it. Pick: Rams 34, Lions 27): https://www.cbssports.com/nfl/news/priscos-week-15-nfl-picks-bills-beat-patriots-in-afc-east-battle-packers-knock-off-broncos-on-road/
NFL Week 15 picks: Upset and score predictions, matchup breakdowns for every game (Rams 33-30, Rams 28-24, Rams 35-27, Rams 34-24, Rams 30-27): https://www.nfl.com/news/nfl-picks-week-15-2025-nfl-season
CBS Dajani and Dubin (Detroit Lions at Los Angeles Rams (-5.5) - Dajani (Rams -5.5): Talk about a get-right game for L.A. last week. The Rams thumped the hapless Arizona Cardinals, 45-17, following their shocking loss to the Carolina Panthers. Now, Matthew Stafford gets his former team -- who he actually has a losing record against. Most bettors probably think this line is too large, but this Lions defense is down several starters -- including the Pro Bowler Brian Branch, who just tore his Achilles. The Lions are 7-6 ATS compared to the Rams' 9-4 ATS record. It may be a sweat in the fourth quarter, but I'll actually lay the points with the favorites … Prediction: Rams 28, Lions 21. Dubin (Lions +5.5): The Lions are once again battered by injuries on defense, having just lost Brian Branch for the season last Thursday in addition to the various other players they already had on injured reserve. But their offense is good enough to keep them in any game with any team -- even one as good as the Rams. Jahmyr Gibbs, Amon-Ra St. Brown and Jameson Williams are so explosive that they can overcome some of the issues Detroit might have up front with L.A.'s defensive line. As long as the protection doesn't totally implode, I like Detroit to keep this close. … Prediction: Rams 30, Lions 26): https://www.cbssports.com/nfl/news/nfl-week-15-picks-experts-falcons-buccaneers-tnf-packers-broncos/
CBS Sullivan (Lions at Rams - Projected score: Rams 30, Lions 27): https://www.cbssports.com/nfl/news/nfl-week-15-picks-predictions-ats-upsets-score-projections/
PFT’s Week 15 2025 NFL picks: Florio vs. Simms (Lions at Rams (-5.5): The Lions are on the ropes. Matthew Stafford hope to punch his former team through. Florio’s pick: Rams 30, Lions 27. Simms’s pick: Rams 38, Lions 35.): https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-15-2025-nfl-picks-florio-vs-simms
FOX Super 6 Contest: Chris 'The Bear' Fallica's NFL Week 15 Picks, Predictions (PREDICTION: Rams 30, Lions 27): https://www.foxsports.com/stories/nfl/fox-super-6-contest-chris-the-bear-fallicas-nfl-week-15-picks-predictions
Lions vs. Rams Final Score Prediction for NFL Week 15 (Can LA Cover at Home?) (Final Score Prediction: Rams 30, Lions 24): https://www.si.com/betting/lions-vs-rams-final-score-prediction-for-nfl-week-15-can-la-cover-at-home
Key Matchups, Predictions for Bills-Patriots and More NFL Week 15 Games (Los Angeles 30, Detroit 27): https://www.si.com/nfl/key-matchups-predictions-bills-patriots-nfl-week-15-games
Lions-Rams Week 15 score predictions from MLive’s beat writers (Both pick the Rams to win by scores of 35-31, 31-24): https://www.mlive.com/lions/2025/12/lions-rams-week-15-score-predictions-from-mlives-beat-writers.html
Last-minute thoughts and predictions (Prediction: Rams 34, Lions 31): https://lionswire.usatoday.com/story/sports/nfl/lions/2025/12/14/last-minute-thoughts-and-predictions-for-lions-vs-rams-in-week-15/87762755007/
Non-Score Predictions:
ESPN (6 pick the Rams to win. 5 pick the Lions to win): https://www.espn.com/nfl/picks
SI (5 pick the Rams. 1 picks the Lions): https://www.si.com/nfl/2025-nfl-week-15-staff-expert-picks
Athletic (5 pick the Rams. 1 picks the Lions): https://www.nytimes.com/athletic/6875812/2025/12/10/nfl-week-15-staff-picks-postseason-stakes/
FTW (All 8 pick the Rams to win): https://ftw.usatoday.com/story/sports/nfl/2025/12/11/nfl-straight-up-picks-week-15-packers-broncos-patriots-bills/87700002007/
CBS (4 pick the Rams to win): https://www.cbssports.com/nfl/picks/experts/straight-up/15/
68 Pick the Rams to win. 15 Pick the Lions to win. (1613-1431/52): Rams 31 Lions 28
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