SN Iyer (Game of the Week: Steelers at Lions (-7, 50 o/u) - Sunday 4:25 p.m. ET, CBS. Aaron Rodgers gets another stop on his NFC North reunion tour with a trip to Ford Field. He will play well with DK Metcalf and the rest of his receivers against a depleted Detroit defense. But the Steelers' defense has enough holes, especially against the run, to help Jamhyr Gibbs and David Montgomery lift Jared Goff to victory. Pick: Lions win 30-24 but fail to cover the spread.): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-against-spread-week-16/cbb3153f63d035ec4d7a69f2
SN Bender (Pittsburgh Steelers at Detroit Lions (-7) - Sunday, 4:25 p.m., CBS. The Lions are still in the NFC playoff hunt, but they'll have to knock off an old foe in Aaron Rodgers, who has kept the Steelers in the AFC North mix. The Lions have not beat the Steelers since a 19-16 victory on Nov. 26, 1998 – the “Coin Flip” game with Jerome Bettis. Detroit changes that with a strong running game led by Jahmyr Gibbs. Pick: Lions 34, Steelers 29): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-16/462d587f5262a948a2423513
Walter football (Week 16 NFL Pick: Lions 38, Steelers 24): https://walterfootball.com/nflpicks2025_16late.php
Pro Picks: Rams, Bears and Panthers will win in first-place showdowns (PITTSBURGH (8-6) at DETROIT (8-6) - Line: Lions minus 7. Aaron Rodgers and the Steelers are back atop the AFC North with the Ravens right behind. They’ve got a difficult challenge against the Lions coming off a Monday night win. The Lions have to win out and get help to make the playoffs. QB Jared Goff and coach Dan Campbell have won 15 straight games off a loss, going 14-1 against the spread in that spot. LIONS: 26-17): https://apnews.com/article/nfl-picks-week-16-b16c2d7163024a31be3960f2db108d72
CBS Prisco (Pittsburgh Steelers at Detroit Lions (-7): This is a big game for both in their playoff quest. The Lions lost last week, while the Steelers are coming off a Monday night win over the Dolphins. The Steelers defense played well in that one, but this is a big step up in terms of matching offensive firepower. Both teams will score, but the Lions will get more. Pick: Lions 33, Steelers 27): https://www.cbssports.com/nfl/news/priscos-week-16-nfl-picks-seahawks-top-rams-on-tnf-packers-edge-bears-jaguars-upset-broncos/
USA TODAY NFL Week 16 picks: Rams or Seahawks in battle for NFC supremacy? (All 6 pick the Lions to win by scores of 31-20, 31-20, 31-23, 30-17, 28-24, 31-20): https://www.usatoday.com/story/sports/nfl-picks/2025/12/18/nfl-week-16-picks-spread-predictions-locks-rams-seahawks-packers-bears/87822493007/
NFL Week 16 picks: Upset and score predictions, matchup analysis for every game (Lions 31-23, Lions 34-23, Lions 33-21, Lions 34-21, Lions 30-21): https://www.nfl.com/news/nfl-picks-week-16-2025-nfl-season
CBS Sullivan (Projected score: Lions 30, Steelers 20): https://www.cbssports.com/nfl/news/nfl-week-16-picks-predictions-ats-upsets-score-projections/
CBS Dajani and Dubin (Dajani (Lions -7): The Steelers are feeling good following their blowout victory over the Miami Dolphins, but good luck outscoring the Lions. This unit leads the NFL with 30.6 points per game and averages 91.8 more yards per game than Pittsburgh. Aaron Rodgers' offense ranks last in the NFL in time of possession (27:26) and offensive plays run per game (55.7). Meanwhile, this Steelers pass defense ranks bottom six in the NFL, so Jared Goff could have a field day. The Lions are desperate for a win, as they would be eliminated from playoff contention with a loss. Prediction: Lions 30, Steelers 20. Dubin (Lions -7): I feel the same way about this game as Dajani does. I just don't think the Steelers can score enough to keep up with the Lions -- even against an injury-ravaged Detroit defense. You can run on the Steelers, as we have seen in recent weeks, and this feels like a game where Jahmyr Gibbs gets back on track in a big way after he struggled to run the ball against the Rams last week. Unless an offensive explosion comes out of nowhere for Pittsburgh, I like the Lions to win big. Prediction: Lions 31, Steelers 17): https://www.cbssports.com/nfl/news/nfl-week-16-expert-picks-head-to-head-against-the-spread-predictions/
PFT’s Week 16 2025 NFL picks: Florio vs. Simms (Steelers at Lions (-7): The Lions’ backs are against the wall, while the Steelers can lose the next two and still have the division come down to Week 18 vs. the Ravens. Florio’s pick: Lions 29, Steelers 21. Simms’s pick: Lions 34, Steelers 21.): https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-16-2025-nfl-picks-florio-vs-simms
Our guide to every Week 16 NFL game: Matchup previews, predictions and what's at stake (Maldonado's pick: Lions 30, Steelers 23. Moody's pick: Lions 34, Steelers 28. Walder's pick: Lions 30, Steelers 20): https://www.espn.com/nfl/story/_/page/viewersguide47337400/nfl-week-16-picks-predictions-schedule-fantasy-football-odds-injuries-stats-2025
Five things to watch as Lions face Steelers in must-win game; plus injury updates (PREDICTION: Lions 28, Steelers 24): https://lionslowdown.com/2025/12/20/five-things-to-watch-as-lions-face-steelers-in-must-win-game-plus-injury-updates/
Lions-Steelers Week 16 score predictions from MLive’s beat writers (All 3 pick the Lions to win by scores of 27-16, 38-24, 31-17): https://www.mlive.com/lions/2025/12/lions-steelers-week-16-score-predictions-from-mlives-beat-writers.html
Pittsburgh Steelers at Detroit Lions odds, picks and predictions (Prediction
Lions 30, Steelers 24): https://sportsbookwire.usatoday.com/story/sports/nfl/2025/12/20/steelers-at-lions-odds-picks-and-predictions/87866103007/
Lions vs. Steelers prediction, pick, odds for Sunday's NFL Week 16 game (Prediction: Lions 29 - Steelers 22): https://sportsbookwire.usatoday.com/story/sports/sports-betting/2025/12/20/lions-vs-steelers-nfl-prediction-odds-12-21-2025/87864787007/
Steelers vs. Lions Final Score Prediction for NFL Week 16 (Can Detroit Cover?) (Final Score Prediction: Lions 30, Steelers 20): https://www.si.com/betting/steelers-vs-lions-final-score-prediction-for-nfl-week-16-can-detroit-cover
Lions OnSI (All 4 pick the Lions to win by scores of 27-23, 28-20, 24-20, 35-24): https://www.si.com/nfl/lions/onsi/news/expert-predictions-will-detroit-lions-defeat-pittsburgh-steelers
NFL.com Video Lions vs. Steelers | Week 16 preview (9 pick the Lions to win by scores of 34-30, 31-13, 28-24, 31-21, 30-26, 31-21, 30-27, 27-20, 24-20. 1 picks the Steelers to win 28-20): https://www.detroitlions.com/video/lions-vs-steelers-week-16-preview
Non-Score Predictions:
SI (6 pick the Lions to win): https://www.si.com/nfl/2025-nfl-week-16-staff-expert-picks
Athletic (All 6 pick the Lions to win): https://www.nytimes.com/athletic/6895648/2025/12/17/nfl-week-16-staff-picks-nfc-showdown/
ESPN (10 pick the Lions to win. 1 picks the Steelers to win): https://www.espn.com/nfl/picks
FTW (8 pick the Lions to win. 1 picks the Steelers to win): https://ftw.usatoday.com/story/sports/nfl/2025/12/18/nfl-straight-up-picks-week-16-fading-packers-bears-rams-seahawks/87812481007/
73 pick the Lions to win. 3 pick the Steelers to win. Average Predicted Score (1396-1011/46): Lions 30 Steelers 22
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