Week 6 Predictions

CBS Breech (Detroit (4-1) at Kansas City (2-3):  I'm not saying I'm concerned about the Chiefs just yet, but I'm not saying I'm not. Heading into Week 6, the Chiefs already have more losses than they had during the entire 2024 season. Also, they're 0-3 in one-score games this year, which is a stat that I can't even comprehend, because Patrick Mahomes doesn't lose one score games. Last year, they went 11-0 in games decided by one score.  I think that I'm trying to say is that this year's Chiefs are not last year's Chiefs.   The Chiefs have already lost to the Chargers, Eagles and Jaguars, and now, they get their toughest test of the season in the Detroit Lions. The Lions will be rolling into Kansas City on a four-game winning streak, which is currently the longest in the NFL.   During their streak, the Lions have averaged 40.3 points per game. Most teams have yet to score 40 points in a single game, the Lions are AVERAGING that over the past four weeks. The Lions offense is so good because it has 10 different ways to beat you. The Lions are the only team in the NFL that has TWO running backs (David Montgomery and Jahmyr Gibbs) who have both gone over 300 rushing yards on the season (To put that in perspective, the Chiefs don't even have a single player who has rushed for more than 200 yards). The Lions rushing tandem could be a problem for a Chiefs defense that has struggled to stop the run this year, and even if they stop the run, Montgomery might just go out and throw a touchdown pass.  The Lions also have three different players who have recorded at least 200 receiving yards through five weeks and one of those players is Jameson Williams, who leads the NFL in yards per catch at 20.3. The Lions also have a defense that can get after the passer, which is something the Chiefs haven't really had to deal with over the past few weeks. Since Week 2, the Chiefs haven't played a single team that ranks in the top-25 in the NFL in sacks. The Lions have 16 sacks on the season, which ranks second in the league this year. That could be trouble for Kansas City.  This game feels like it's going to be a shootout, so I'm going to take the team that has more firepower, and for once, it's not the team that Patrick Mahomes is playing for.  PICK: Lions 30-27 over Chiefs):  https://www.cbssports.com/nfl/news/nfl-week-6-picks-score-predictions-lions-stun-chiefs-49ers-upset-buccaneers/

SN Iyer (Game of the Week: Lions at Chiefs (-1, 49.5 o/u) - Sunday 8:20 p.m. ET, NBC/Peacock.  The Lions are becoming more of a complete team. Jared Goff can spread the ball around well based on the best passing matchups. The running game never lets them down. Aidan Hutchinson and Brian Branch are revving up the defense. The Chiefs are battling a touch-short week and don't have the same level of diversity and explosiveness around their quarterback, including a limited running game. Goff continues to be better on the road for a second straight Arrowhead win for Detroit.  Pick: Lions win 27-24.):  https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-against-spread-week-6/210e41fab29fde9fd85fb0af

SN Bender (Detroit Lions at Kansas City Chiefs (-1).  This might be a pick ‘em by kickoff given how well the Lions have played since the Week 1 loss against Green Bay. The Chiefs' front-loaded schedule continues, and Detroit has taken advantage of a plus-seven turnover ratio the last four games. The Lions beat Kansas City 21-20 in the 2023 season opener – so the confidence is there.   Pick: Lions 30, Chiefs 24):  https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-6/8f6ce7cb6d9d4c7e644ac873

CBS Dajani and Taranto (Detroit Lions at Kansas City Chiefs (-2.5) (SNF) - Dajani (Lions +2.5): The Lions have won four straight games after losing the season opener to the Green Bay Packers, which is actually the longest active win streak in the NFL. Detroit is averaging 40.3 points per contest over this four-game stretch. Is anyone missing Ben Johnson yet? Playing in Arrowhead is tough, and the Chiefs definitely won the "battle of the injury reports" on Wednesday. Kansas City had full attendance, while Terrion Arnold, Zach Cunningham, Taylor Decker, Kerby Joseph and Amon-Ra St. Brown missed practice. Still, Jared Goff is one of just two players to beat Mahomes multiple times while having zero losses to him (the other is Ryan Tannehill), and I believe the Lions can just simply outscore the Chiefs. But I'm more comfortable taking the Over. Prediction: Lions 35, Chiefs 31.  Taranto (Lions +2.5): Over the past few years, I've gotten the sense that the Lions have been one of the only few teams in the NFL that truly hasn't been afraid of the Chiefs dynasty. There's especially nothing for them to fear now, as the Chiefs are coming off of a loss to the Jaguars that dropped them to 2-3 and look as vulnerable and pedestrian as they have in a very long time. Winning in Arrowhead is a tough assignment, but that's what the Lions did on NFL opening night back in 2023. Detroit knows it can do it, and with four wins in a row to shake off its Week 1 loss, I expect that's exactly what it'll do. Prediction: Lions 31, Chiefs 27):  https://www.cbssports.com/nfl/news/nfl-week-6-betting-picks-predictions-odds/

CBS Sullivan (Detroit Lions at Kansas City Chiefs - The Chiefs will probably figure it out by the time the regular season comes to an end, and will again look like a Super Bowl contender, but I don't see it right now. They are unable to hang with even fringe playoff contenders with their two victories on the year coming against the New York Giants and an injury-filled Baltimore Ravens squad. When the games are close, they've fallen flat, owning a 0-3 record in one-score games this season. With this spread sitting at Chiefs -2.5, I think we'll see more of the same. I have a hard time imagining this current version of the Chiefs offense keeping up with the Lions, who are averaging 34.8 points per game (most in the NFL). Dan Campbell's team comes into Arrowhead Stadium with a 10-1 record on the road dating back to the start of last season. This could be another stellar showing from Detroit's backfield duo of David Montgomery and Jahmyr Gibbs as they square off against a Chiefs run defense that is giving up 4.8 yards per carry (tied for fifth-highest in the NFL).  Projected score: Lions 30, Chiefs 23):  https://www.cbssports.com/nfl/news/nfl-week-6-picks-predictions-best-bets/

PFT’s Week 6 2025 NFL picks: Florio vs. Simms (Lions at Chiefs (-2.5) - Why are the Chiefs favored?  Florio’s pick: Lions 30, Chiefs 24.  Simms’s pick: Lions 30, Chiefs 21.):  https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-6-2025-nfl-picks-florio-vs-simms

Five things to watch as Lions face Chiefs in prime time action (PREDICTION: Lions 28, Chiefs 27):  https://lionslowdown.com/2025/10/11/five-things-to-watch-as-lions-face-chiefs-in-prime-time-action/

SI All Lions (All 4 pick the Lions to win by scores of 27-24, 24-20, 37-34, 27-24):  https://www.si.com/nfl/lions/news/expert-predictions-will-detroit-lions-defeat-kansas-city-chiefs

Our guide to every Week 6 NFL game: Matchup previews, predictions, picks and nuggets (Maldonado's pick: Chiefs 27, Lions 21.  Moody's pick: Lions 34, Chiefs 24.  Walder's pick: Lions 30, Chiefs 23):  https://www.espn.com/nfl/story/_/id/46523058/nfl-week-6-picks-predictions-schedule-fantasy-football-odds-injuries-stats-2025

USA Today (5 pick the Lions to win by scores of 31-30, 31-23, 30-27, 28-24, 28-27.  1 picks KC to win 28-27):  https://www.usatoday.com/story/sports/nfl-picks/2025/10/09/nfl-week-6-picks-spread-predictions-locks-chiefs-lions/86590387007/

NFL.com (7 pick the Lions to win by scores of 31-30, 30-27, 26-23, 27-24, 31-28, 27-24, 30-28.  3 pick KC to win by scores of 28-27, 27-24, 30-27):  https://www.nfl.com/videos/lions-vs-chiefs-preview-week-6

NFL Week 6 picks & predictions: Eagles beat Giants in tight TNF showdown (Lions 27-24, Chiefs 27-24, Chiefs 30-28, Chiefs 27-24, Lions 28-25):  https://www.nfl.com/news/nfl-picks-week-6-2025-nfl-season

Walter football (Week 6 NFL Pick: Chiefs 31, Lions 24):  https://walterfootball.com/nflpicks2025_06late.php

CBS Prisco (Detroit Lions at Kansas City Chiefs (-2.5):  The Chiefs are on a short week off a tough loss to the Jaguars on Monday night. But they face a banged-up Lions team. The Chiefs are in desperation mode, and I think that will show here. The Chiefs will win a high-scoring game, taking advantage of the injured Lions defense. Patrick Mahomes will win it late.  Pick: Chiefs 34, Lions 30):  https://www.cbssports.com/nfl/news/pete-priscos-week-6-nfl-picks-predictions-chiefs-lions-chargers-dolphins/

Pro Picks: Chiefs will beat the Lions in a marquee matchup that still could be a Super Bowl preview (A Lions-Chiefs matchup was considered a potential Super Bowl preview when the schedule came out.  It still could be considering the state of the AFC.  Jared Goff leads a dynamic Lions offense against Patrick Mahomes and the inconsistent Chiefs on Sunday night in Kansas City in one of the biggest games in Week 6.  Detroit (4-1) rebounded from a lopsided loss to Green Bay in Week 1 to win four in a row. The Chiefs (2-3) were on the right track with two straight wins after opening 0-2 but gave up a final-minute score to lose to Jacksonville on Monday night.  Still, Kansas City is only one game behind in the AFC West and two behind the Bills (4-1), Jaguars (4-1) and Colts (4-1). The Chiefs visit Buffalo in Week 9 so they just need to go on a run.  The Lions are 12-2 in prime-time games with Goff and coach Dan Campbell but both of those losses came as underdogs.  Despite owning a losing record, the Chiefs are 2 1/2-point favorites, according to BetMGM Sportsbook.  Pro Picks leans toward the home team.  CHIEFS: 30-27):  https://apnews.com/article/nfl-week-6-picks-fb45d5d7d19c04a044811d6145bfe46c

Key Matchups, Predictions for Chiefs-Lions, Seahawks-Jaguars and More (Lions (4–1) at Chiefs (2–3) Spread: Chiefs -2.5.  Key matchup: Patrick Mahomes vs. Detroit’s corners.  Key stat: Mahomes is sixth with 1,257 passing yards.  This game might be a race to 30 points. If that’s the case, the deciding factor will likely be whether the Lions can hold up in coverage against Mahomes.  Detroit will be without its top three corners on the depth chart from when the summer began, including Terrion Arnold, D.J. Reed and Ennis Rakestraw Jr. That doesn’t bode well against the Chiefs, who over the past two weeks have racked up 858 total yards and 65 points against the Ravens and Jaguars.   Lions first-year coordinator Kelvin Sheppard has been blitz-happy, ranking ninth in sending extra rushers (28.8%). If the Chiefs can handle the pressure, Mahomes will have one-on-one opportunities against Avonte Maddox, Rock Ya-Sin and Amik Robertson. It’s a dangerous game, and one that might force Sheppard to play more conservatively.   If there’s ever a game where the Chiefs hand the ball to Mahomes and ask him to throw 40-plus times, this might be it.   Verdict: Kansas City 34, Detroit 31):  https://www.si.com/nfl/nfl-week-6-key-matchups-predictions-chiefs-lions-seahawks-jaguars

Cynthia Week 6 Score Projections (KC wins 25-24):  https://www.nfl.com/videos/week-6-score-projections

Lions vs Chiefs: Last-minute thoughts and final score prediction (Chiefs 30, Lions 27):  https://lionswire.usatoday.com/story/sports/nfl/lions/2025/10/12/lions-vs-chiefs-preview-breakdown-game-matchup-final-prediction/86604808007/

Non-Score Picks:

CBS (4 pick the Lions.  1 picks KC):  https://www.cbssports.com/nfl/picks/experts/straight-up/6/

SI (5 pick the Lions.  2 pick KC):  https://www.si.com/nfl/2025-nfl-week-6-staff-expert-picks

FTW (5 pick the Lions.  2 pick KC):   https://www.si.com/nfl/2025-nfl-week-6-staff-expert-picks

ESPN (6 pick the Lions to win.  5 pick KC to win):  https://www.espn.com/nfl/picks

48 Pick the Lions to win.  23 Pick KC to win.  Average Predicted Score (1220-1047/42):  Lions 29 KC 27