SN Bender (Cleveland Browns at Detroit Lions (-8.5) Sunday, 1 p.m., Fox. The Browns are riding high with a nasty defense that showed out against the Packers. The Lions are a different story at home. Look for Dan Campbell to stay aggressive in the passing game with Jared Goff, who had five TD passes at home in Week 2. Detroit's defense will have to slow Quinshon Judkins, who had 18 carries for 94 yards in Week 3. Pick: Lions 27, Browns 14): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-4/1e36ed5c1a640b97027870d7
SN Iyer (Browns at Lions (-8.5, 45.5 o/u) Sunday 1 p.m. ET, Fox. The Lions play their best offense at home. The Browns play their best defense at home. Nothing needs to give here with Detroit rocking Cleveland with explosive pass plays and stopping the run. Pick: Lions win 27-14 and cover the spread.): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-4/1e36ed5c1a640b97027870d7
Walter football (Week 4 NFL Pick: Lions 24, Browns 17): https://walterfootball.com/nflpicks2025_04early.php
CBS Prisco (Cleveland Browns (+8.5) at Detroit Lions: The Lions are riding high after blowing out the Ravens on Monday night. They were dominant on offense and the defense got after Lamar Jackson. On a short week playing this Browns defense won't be easy. Cleveland is the top-ranked defense in the league. That will be in play here as they keep the game close. Pick: Lions 23, Browns 17): https://www.cbssports.com/nfl/news/priscos-week-4-nfl-picks-buccaneers-eagles-chiefs-ravens-packers-cowboys/
NFL.com (All 10 pick the Lions to win by scores of 24-20, 27-7, 31-14, 20-13, 24-13, 27-16, 20-10, 20-15, 27-16, 20-13): https://www.detroitlions.com/video/lions-vs-browns-week-4-preview
Pro Picks: Micah Parsons and the Packers will beat Dak Prescott and the Cowboys convincingly (Cleveland (1-2) at Detroit (2-1) - Line: Lions minus 9 1/2. Myles Garrett and a tough defense will keep the Browns in games. The Lions didn’t need much time to adjust to new coordinators. Their offense and defense are clicking. Both teams are 2-1 ATS this season. The Lions have to avoid a letdown on a short week after a huge road win. LIONS: 24-13): https://apnews.com/article/parsons-prescott-cowboys-packers-jones-328d08ff217bfa8a1dbe03a1eb3b2f39
USA Today (All 6 pick the Lions to win by scores of 24-16, 27-13, 22-12, 27-16, 26-14, 24-13): https://www.usatoday.com/story/sports/nfl-picks/2025/09/25/nfl-week-4-picks-spread-predictions-locks-cowboys-packers/86339695007/
CBS Sullivan (Browns at Lions - Projected score: Lions 30, Browns 16): https://www.cbssports.com/nfl/news/nfl-week-4-picks-ravens-chiefs-chargers-jaxson-dart/
PFT’s Week 4 2025 NFL picks: Florio vs. Simms (Browns at Lions (-10) - The Lions are still the Lions, and the Browns lack the offensive punch to keep pace. Florio’s pick: Lions 35, Browns 6. Simms’s pick: Lions 28, Browns 13.):..https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-4-2025-nfl-picks-florio-vs-simms
NFL Week 4 picks: Seahawks-Cardinals prediction unanimous; Vikings top Steelers in Dublin (Lions 26-17, Lions 30-16, Lions 26-18, Lions 28-17, Lions 26-17): https://www.nfl.com/news/nfl-picks-week-4-2025-nfl-season
Our guide to every Week 4 NFL game: Matchup previews, predictions, picks and nuggets (Maldonado's pick: Lions 38, Browns 7. Moody's pick: Lions 30, Browns 16. Walder's pick: Lions 24, Browns 13): https://www.espn.com/nfl/story/_/id/46355188/nfl-week-4-picks-predictions-schedule-fantasy-football-odds-injuries-stats-2025
CBS Dajani (Lions (-9.5) 28-17 over Browns): https://www.cbssports.com/nfl/news/nfl-week-4-picks-odds-carson-wentz-vikings-defeat-steelers-broncos-blast-bengals/
Detroit News (All 4 pick the Lions to win by scores of 34-13, 31-14, 28-20, 27-13): https://www.detroitnews.com/story/sports/nfl/lions/2025/09/26/predictions-detroit-lions-vs-cleveland-browns/86314364007/
Browns vs. Lions Final Score Prediction for NFL Week 4 (Bet on Detroit to Cover) (Browns vs. Lions Final Score Prediction - Earlier this week, SI’s NFL betting insider Iain MacMillan shared his favorite bet for this game in his Road to 272 column, and he’s taking the Lions to cover: The Cleveland Browns have managed to hang on against two of their three opponents in terms of covering the spread, but I still think they're one of the worst teams in the league. Their offense is atrocious, ranking 29th in success rate and 30th in EPA per play. They're going to have to do better than that to keep up with the elite Lions offense, especially with the Browns playing on the road. I think Detroit runs away with this one in impressive fashion. The Cleveland defense has been impressive this season, but this a brutal matchup on the road against a Detroit team that is No. 2 in EPA/Play on offense. On top of that, the Detroit defense is No. 1 in EPA/Rush, which could make things tough on Joe Flacco and company moving the ball. The Cleveland passing game has been shaky, and the lone bright spot was last week’s showing from rookie running back Quinshon Judkins (18 carries, 94 yards). I’ll back Detroit to win big at home. Final Score Prediction: Lions 27, Browns 13): https://www.si.com/betting/browns-vs-lions-final-score-prediction-for-nfl-week-4-bet-on-detroit-to-cover
Lions-Browns Week 4 score predictions from MLive's beat writers (24-7, 28-14, 31-10): https://www.mlive.com/lions/2025/09/lions-browns-week-4-score-predictions-from-mlives-beat-writers.html
Sports Book wire (Prediction: Lions 39 - Browns 9): https://sportsbookwire.usatoday.com/story/sports/sports-betting/2025/09/27/lions-vs-browns-nfl-prediction-odds-9-28-2025/86393345007/
Non-Score Predictions:
ESPN (All 11 pick the Lions to win): https://www.espn.com/nfl/picks
SI (All 7 pick the Lions to win): https://www.si.com/nfl/nfl-week-4-picks-from-the-mmqb-staff-chiefs-host-ravens-in-must-win-matchup
CBS (All 5 pick the Lions to win): https://www.cbssports.com/nfl/picks/experts/straight-up/4/
63 pick the Lions to win. 1 picks the Browns to win. Average Predicted Score (1150-602/43): Lions 27 Browns 14.
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