SN Iyer (New York Giants at Detroit Lions (-10.5): The Lions are 3-1 at home, and they won those games by an average margin of 23.3 points per game. Jameis Winston had two turnovers in the loss to the Packers in Week 12. Detroit will get on track in a convincing fashion here to get ready for the rematch with Green Bay on Thanksgiving. Pick: Lions 31, Giants 16): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-week-12/c3130a9d6bb81fc6f472fa0f
SN Bender (Giants at Lions (-10.5, 50.5 o/u) - The Lions are back home in the dome against a defense that cannot stop the run vs. either speed or power backs. The Giants also give up a lot to wide receivers in terms of big plays downfield. That's a terrible 1-2 gut punch vs. Jared Goff, who will be eager to get back on track with Jahmyr Gibbs, David Montgomery, Amon-Ra St. Brown and Jameson Williams boosting him plenty away from the elements and the Eagles. Pick: Lions win 42-14 and cover the spread.): https://www.sportingnews.com/us/nfl/news/nfl-picks-predictions-against-spread-week-12/555140416d088b095d920be9
Walter football (Week 12 NFL Pick: Lions 38, Giants 17): https://walterfootball.com/nflpicks2025_12early.php
CBS Prisco (New York Giants at Detroit Lions (-10.5): The Lions are coming off a tough loss to the Eagles and now must regroup at home against a Giants team that isn't going anywhere. The Giants might have Jaxson Dart back at quarterback this week, but it won't matter who plays quarterback. This will be about the Lions offense getting back on track after disappointing last week. They roll. Pick: Lions 31, Giants 10): https://www.cbssports.com/nfl/news/pete-priscos-week-12-nfl-picks-chiefs-upend-colts-browns-top-raiders-shedeur-sanders/
NFL.com (All 10 pick the Lions to win by scores of 28-21, 27-17, 28-16, 31-17, 30-14, 26-20, 37-14, 30-17, 31-20, 33-20): https://www.nfl.com/videos/giants-vs-lions-preview-week-12
Pro Picks: Desperate Chiefs will beat the Colts to go back over .500 (NEW YORK GIANTS (2-9) at DETROIT (6-4) - Line: Lions minus 10 1/2. The Giants’ biggest highlight of the week will be Cam Skattebo and teammates getting into it on WWE’s “Monday Night Raw.” The Lions need to get back on track after a lackluster offensive effort in Philadelphia. Back indoors, Jared Goff should rebound from a poor performance. Detroit’s defense stood out against the Eagles and now takes on the sluggish Giants offense. The Lions are 13-0 straight up and against the spread off a loss since November 2022. BEST BET: LIONS: 33-17): https://apnews.com/article/mahomes-chiefs-jones-taylor-colts-adecadf77d42b823c4eec40a67a64c1b
NFL Week 12 picks: Upset and score predictions, matchup breakdowns for every game (Lions 31-20, Lions 31-23, Lions 34-18, Lions 40-17, Lions 31-19): https://www.nfl.com/news/nfl-week-12-picks-upset-and-score-predictions-matchup-breakdowns-for-every-game
CBS Sullivan (Giants at Lions - Projected score: Lions 30, Giants 17): https://www.cbssports.com/nfl/news/nfl-week-12-picks-predictions-underdogs-upsets/
PFT’s Week 12 2025 NFL picks, Florio vs. Simms (Giants at Lions (-10.5) - This is not a good week to be playing the Lions in Detroit. Florio’s pick: Lions 45, Giants 20. Simms’s pick: Lions 38, Giants 20.): https://www.nbcsports.com/nfl/profootballtalk/rumor-mill/news/pfts-week-12-2025-nfl-picks-florio-vs-simms
USA Today (All 6 pick the Lions to win by scores of 34-17, 34-24, 44-27, 31-13, 28-20, 35-21): https://www.usatoday.com/story/sports/nfl-picks/2025/11/20/nfl-week-12-picks-spread-predictions-locks-chiefs-colts/87366103007/
Lions-Giants Week 12 score predictions from MLive’s beat writers (All 3 pick the Lions to win by scores of 27-10, 24-6, 35-17): https://www.mlive.com/lions/2025/11/lions-giants-week-12-score-predictions-from-mlives-beat-writers.html
Our guide to every Week 12 NFL game: Matchup previews, predictions, picks and nuggets (Maldonado's pick: Lions 34, Giants 10. Moody's pick: Lions 34, Giants 17. Walder's pick: Lions 25, Giants 24): https://www.espn.com/nfl/story/_/page/viewersguide47026826/nfl-week-12-picks-predictions-schedule-fantasy-football-odds-injuries-stats-2025
CBS Dajani (Lions (-10.5) 30-17 over Giants): https://www.cbssports.com/nfl/news/nfl-week-12-picks-odds-best-bets/
Giants vs. Lions Final Score Prediction for NFL Week 12 (Can Detroit Cover?) (Final Score Prediction: Lions 31, Giants 20): https://www.si.com/betting/giants-vs-lions-final-score-prediction-for-nfl-week-12-can-detroit-cover
Lions vs. Giants 2025 Prediction, Odds, Picks - Nov 23 (Prediction: Lions 32 - Giants 18): https://www.foxsports.com/articles/nfl/lions-vs-giants-2025-prediction-odds-picks-nov-23
Giants Wire New York Giants vs. Detroit Lions: Week 12 staff picks and predictions (37-16, 34-24, 38-20, 34-20): https://giantswire.usatoday.com/story/sports/nfl/giants/2025/11/22/new-york-giants-detroit-lions-week-12-staff-picks-predictions/87392521007/
Five things to watch as Lions face the Giants; plus injury update, prediction (PREDICTION: Lions 38, Giants 17): https://lionslowdown.com/2025/11/22/five-things-to-watch-as-lions-face-the-giants-plus-injury-update-prediction/
Detroit Lions vs New York Giants prediction, scouting report (The pick: Lions 31, Giants 17): https://www.freep.com/story/sports/nfl/lions/2025/11/22/detroit-lions-scouting-report-vs-ny-giants-offense-back-on-track/87376139007/
Lions vs Giants: Last-minute thoughts and final score prediction (Final score prediction - Early in the week, I had this game pegged as a one-sided romp for the Lions. And it still might be. It probably should be, given the Giants injuries. The Lions bounce back so well from losses under Dan Campbell, and this shouldn't be an exception. Winston at QB instead of Dart makes the prediction a little tougher, but the 12.5-point line looks ripe for the picking. Lions 30, Giants 13): https://lionswire.usatoday.com/story/sports/nfl/lions/2025/11/23/lions-vs-giants-matchup-breakdown-preview-final-score-prediction/87424978007/
Expert Predictions: Will Detroit Lions Defeat New York Giants? (38-13, 31-17, 31-13, 31-20): https://www.si.com/nfl/lions/onsi/news/expert-predictions-will-detroit-lions-defeat-new-york-giants
Freep (All 5 pick the Lions to win by scores of 34-17, 32-16, 30-20, 35-17, 34-19): https://www.freep.com/story/sports/nfl/lions/2025/11/23/lions-giants-picks-predictions/87400000007/
New York Post Giants vs. Lions: Preview, prediction, what to watch for in Week 12 (Paul’s pick - No Jaxson Dart sure makes this game less interesting, doesn’t it? Jameis Winston can still fling it, but he flirted with several would-be interceptions last week. Try to find a matchup where the Giants have any advantage at all. The Lions are 6-4 and in a fight for their playoff lives — they will be in no mood to mess around here. Lions 31, Giants 16): https://nypost.com/2025/11/23/sports/giants-vs-lions-preview-prediction-what-to-watch-for-in-week-12/
Non-Score Predictions:
ESPN (11 pick the Lions to win): https://www.espn.com/nfl/picks
FTW (All 9 pick the Lions to win): https://ftw.usatoday.com/story/sports/nfl/2025/11/20/nfl-straight-up-picks-week-12-inscrutable-nfc-north-buccaneers-rams/87350580007/
SI (All 6 pick the Lions to win): https://www.si.com/nfl/2025-nfl-week-12-staff-expert-picks
CBS (All 5 pick the Lions to win): https://www.cbssports.com/nfl/picks/experts/straight-up/12/
Athletic (All 5 pick the Lions to win): https://www.nytimes.com/athletic/6818487/2025/11/20/nfl-week-12-expert-picks-chiefs-packers/
90 pick the Lions to win. Average Predicted Score (1840-985/56): Lions 33 Giants 18
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